The Preventive Misconception: Experiences from CAPRISA 004
نویسندگان
چکیده
منابع مشابه
Limited HIV-1 superinfection in seroconverters from the CAPRISA 004 Microbicide Trial.
HIV-1 superinfection (SI) occurs when an infected individual acquires a distinct new viral strain. The rate of superinfection may be reflective of the underlying HIV risk in a population. The Centre for the AIDS Programme of Research in South Africa (CAPRISA) 004 clinical trial demonstrated that women who used a tenofovir-containing microbicide gel had lower rates of HIV infection than women us...
متن کاملTrial participation disclosure and gel use behavior in the CAPRISA 004 tenofovir gel trial
Disclosure, or open communication, by female microbicide trial participants of their trial participation and use of an investigational HIV prevention drug to a sexual partner may affect participants' trial product usage behavior and contribute to poor adherence. With mixed results from recent microbicide clinical trials being linked to differing participant adherence, insights into the communic...
متن کاملCAPRISA 004 tenofovir microbicide trial: no impact of tenofovir gel on the HIV transmission bottleneck.
Alterations of the genital mucosal barrier may influence the number of viruses transmitted from a human immunodeficiency virus-infected source host to the newly infected individual. We used heteroduplex tracking assay and single-genome sequencing to investigate the effect of a tenofovir-based microbicide gel on the transmission bottleneck in women who seroconverted during the CAPRISA 004 microb...
متن کاملSafety of tenofovir gel, a vaginal microbicide, in South African women: results of the CAPRISA 004 Trial.
BACKGROUND Tenofovir gel, used vaginally before and after coitus, reduced women's acquisition of HIV by 39%. This is a safety assessment of tenofovir gel, including renal, bone, gastrointestinal, genital and haematological parameters. METHODS In the Centre for the AIDS Programme of Research in South Africa (CAPRISA) 004, a double-blind, randomized placebo-controlled trial, 445 of the 889 elig...
متن کاملGenital Tenofovir Concentrations Correlate With Protection Against HIV Infection in the CAPRISA 004 Trial: Importance of Adherence for Microbicide Effectiveness.
OBJECTIVE The CAPRISA 004 trial showed that coitally dosed tenofovir 1% gel reduced HIV acquisition by 39% overall and 54% when used consistently. The objective of this analysis was to ascertain its pharmacokinetic-pharmacodynamic relationship to protect against HIV acquisition. DESIGN Genital and systemic tenofovir concentrations in 34 women who acquired HIV (cases) were compared with 302 ra...
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ژورنال
عنوان ژورنال: AIDS and Behavior
سال: 2014
ISSN: 1090-7165,1573-3254
DOI: 10.1007/s10461-014-0771-6